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Atorvastatin ameliorated PM2.5-induced atherosclerosis in rats.
- Source :
- Archives of Environmental & Occupational Health; 2023, Vol. 78 Issue 5, p267-272, 6p
- Publication Year :
- 2023
-
Abstract
- PM2.5 provokes atherosclerotic events. Atorvastatin presents anti-inflammatory and antioxidant activities, and may ameliorate PM2.5-induced atherosclerosis development. The purpose of this study was to investigate the cardiotoxic effect of fine particulate matter (PM<subscript>2.5</subscript>) on atherosclerosis (AS) in rats, and the intervention effects of atorvastatin (ATO) on PM<subscript>2.5</subscript>-induced AS development. AS model was established using 32 male Wistar rats through intraperitoneal injection of vitamin D3 combined with a high-fat diet (10% fat and 4% cholesterol). The rats were randomly divided into 4 groups: control group, PM<subscript>2.5</subscript>-exposed group, ATO group, and ATO treated PM<subscript>2.5</subscript>-exposed group. PM<subscript>2.5</subscript> increased levels of TC, TG, LDL, MDA, IL-6, and TNF-α, as well as decreased SOD levels. Besides, PM<subscript>2.5</subscript> also enhanced AI. After the treatment of ATO, most levels of various contents in serum, including TC, TG, LDL, MDA, IL-6, TNF-α, hS-CRP, and ox-LDL, significantly decreased compared to the PM<subscript>2.5</subscript>-exposed group. Moreover, after the treatment of ATO, AI was significantly reduced compared to the PM<subscript>2.5</subscript>-exposed group. In addition, PM<subscript>2.5</subscript> exacerbated the nuclear translocation and ATO resulted in an obvious decrease in PM<subscript>2.5</subscript>-induced nuclear translocation. The present study suggests that PM<subscript>2.5</subscript> could induce oxidative damage and systemic inflammatory response in atherosclerosis model rats, while ATO could ameliorate PM<subscript>2.5</subscript>-induced atherosclerosis development, possibly by lowering lipid, inhibiting inflammation, and suppressing oxidation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19338244
- Volume :
- 78
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Archives of Environmental & Occupational Health
- Publication Type :
- Academic Journal
- Accession number :
- 168582495
- Full Text :
- https://doi.org/10.1080/19338244.2023.2166892