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Effects of M-DEPTH Model of Depression Care on Maternal HIV Viral Suppression and Adherence to the PMTCT Care Continuum Among HIV-Infected Pregnant Women in Uganda: Results from a Cluster Randomized Controlled Trial at Pregnancy Completion.
- Source :
- AIDS & Behavior; Sep2023, Vol. 27 Issue 9, p2902-2914, 13p, 2 Diagrams, 4 Charts, 1 Graph
- Publication Year :
- 2023
-
Abstract
- Perinatal depression has been shown to impede adherence to antiretroviral therapy (ART) and the prevention of mother-to-child transmission (PMTCT) care continuum; therefore, treating perinatal depression may result in increased viral suppression and PMTCT adherence. We examined the effects of the M-DEPTH (Maternal Depression Treatment in HIV) depression care model (including antidepressants and individual Problem Solving Therapy) on depression, maternal viral suppression and adherence to PMTCT care processes in an ongoing cluster-randomized controlled trial of 391 HIV-infected pregnant women (200 usual care; 191 intervention) with at least mild depressive symptoms enrolled across 8 antenatal care clinics in Uganda. At baseline, 68.3% had clinical depression and 41.7% had detectable HIV viral load. Adjusted repeated-measures multivariable regression models found that the intervention group was nearly 80% less likely to be clinically depressed [Adjusted OR (95% CI) 0.22 (0.05, 0.89)] at the 2-month post-pregnancy assessment, compared to the control group. However, the intervention and control groups did not differ meaningfully on maternal viral suppression, ART adherence, and other PMTCT care processes and outcomes. In this sample of women who were mostly virally suppressed and ART adherent at baseline, the depression care model had a strong effect on depression alleviation, but no downstream effects on viral suppression or other PMTCT care processes. Trial Registration NIH Clinical Trial Registry NCT03892915 (clinicaltrials.gov). [ABSTRACT FROM AUTHOR]
- Subjects :
- COMMUNICABLE disease treatment
HIV prevention
COMMUNICABLE diseases
CONFIDENCE intervals
VIRAL load
WOMEN
PREGNANT women
CONTINUUM of care
COMPARATIVE studies
PREGNANCY complications
MENTAL depression
DESCRIPTIVE statistics
RESEARCH funding
PRENATAL care
PATIENT compliance
ODDS ratio
VERTICAL transmission (Communicable diseases)
PSYCHOLOGY of HIV-positive persons
Subjects
Details
- Language :
- English
- ISSN :
- 10907165
- Volume :
- 27
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- AIDS & Behavior
- Publication Type :
- Academic Journal
- Accession number :
- 168593443
- Full Text :
- https://doi.org/10.1007/s10461-023-04014-2