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Anticancer Activity of Diosgenin and Its Molecular Mechanism.
- Source :
- Chinese Journal of Integrative Medicine; Aug2023, Vol. 29 Issue 8, p738-749, 12p
- Publication Year :
- 2023
-
Abstract
- Diosgenin, a steroidal sapogenin, obtained from Trigonella foenum-graecum, Dioscorea, and Rhizoma polgonati, has shown high potential and interest in the treatment of various cancers such as oral squamous cell carcinoma, laryngeal cancer, esophageal cancer, liver cancer, gastric cancer, lung cancer, cervical cancer, prostate cancer, glioma, and leukemia. This article aims to provide an overview of the in vivo, in vitro, and clinical studies reporting the diosgenin's anticancer effects. Preclinical studies have shown promising effects of diosgenin on inhibiting tumor cell proliferation and growth, promoting apoptosis, inducing differentiation and autophagy, inhibiting tumor cell metastasis and invasion, blocking cell cycle, regulating immunity and improving gut microbiome. Clinical investigations have revealed clinical dosage and safety property of diosgenin. Furthermore, in order to improve the biological activity and bioavailability of diosgenin, this review focuses on the development of diosgenin nano drug carriers, combined drugs and the diosgenin derivatives. However, further designed trials are needed to unravel the diosgenin's deficiencies in clinical application. [ABSTRACT FROM AUTHOR]
- Subjects :
- STEROID drugs
THERAPEUTIC use of antineoplastic agents
IN vitro studies
STOMACH tumors
DRUG efficacy
IN vivo studies
STEROIDS
AUTOPHAGY
GUT microbiome
BIOAVAILABILITY
ANTINEOPLASTIC agents
APOPTOSIS
HEAD & neck cancer
MOLECULAR biology
CELLULAR signal transduction
CELL proliferation
DRUG development
SQUAMOUS cell carcinoma
ESOPHAGEAL tumors
PATIENT safety
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 16720415
- Volume :
- 29
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Chinese Journal of Integrative Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 169780603
- Full Text :
- https://doi.org/10.1007/s11655-023-3693-1