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Multiscale entropy analysis of heart rate variability in heart failure, hypertensive, and sinoaortic-denervated rats: classical and refined approaches.

Authors :
Virgilio Silva, Luiz Eduardo
Maria Lataro, Renata
Airton Castania, Jaci
Aguiar da Silva, Carlos Alberto
Valencia, Jose Fernando
Murta Jr., Luiz Otavio
Cesar Salgado, Helio
Fazan Jr., Rubens
Porta, Alberto
Source :
American Journal of Physiology: Regulatory, Integrative & Comparative Physiology; Jul2016, Vol. 311 Issue 1, pR150-R156, 7p, 1 Chart, 2 Graphs
Publication Year :
2016

Abstract

The analysis of heart rate variability (HRV) by nonlinear methods has been gaining increasing interest due to their ability to quantify the complexity of cardiovascular regulation. In this study, multiscale entropy (MSE) and refined MSE (RMSE) were applied to track the complexity of HRV as a function of time scale in three pathological conscious animal models: rats with heart failure (HF), spontaneously hypertensive rats (SHR), and rats with sinoaortic denervation (SAD). Results showed that HF did not change HRV complexity, although there was a tendency to decrease the entropy in HF animals. On the other hand, SHR group was characterized by reduced complexity at long time scales, whereas SAD animals exhibited a smaller short- and long-term irregularity. We propose that short time scales (1 to 4), accounting for fast oscillations, are more related to vagal and respiratory control, whereas long time scales (5 to 20), accounting for slow oscillations, are more related to sympathetic control. The increased sympathetic modulation is probably the main reason for the lower entropy observed at high scales for both SHR and SAD groups, acting as a negative factor for the cardiovascular complexity. This study highlights the contribution of the multiscale complexity analysis of HRV for understanding the physiological mechanisms involved in cardiovascular regulation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03636119
Volume :
311
Issue :
1
Database :
Complementary Index
Journal :
American Journal of Physiology: Regulatory, Integrative & Comparative Physiology
Publication Type :
Academic Journal
Accession number :
170030855
Full Text :
https://doi.org/10.1152/ajpregu.00076.2016