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HTLV-1 p12 modulates the levels of prion protein (PrPC) in CD4+ T cells.
- Source :
- Frontiers in Microbiology; 2023, p1-13, 13p
- Publication Year :
- 2023
-
Abstract
- Introduction: Infection with human T cell lymphotropic virus type 1 (HTLV-1) is endemic in Brazil and is linked with pro-inflammatory conditions including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic neuroinflammatory incapacitating disease that culminates in loss of motor functions. The mechanisms underlying the onset and progression of HAM/TSP are incompletely understood. Previous studies have demonstrated that inflammation and infectious agents can affect the expression of cellular prion protein (PrPC) in immune cells. Methods: Here, we investigated whether HTLV-1 infection affected PrPC content in cell lines and primary CD4<superscript>+</superscript>cells in vitro using flow cytometry and western blot assays. Results: We found that HTLV-1 infection decreased the expression levels of PrPC and HTLV-1 Orf I encoded p12, an endoplasmic reticulum resident protein also known to affect post-transcriptionally cellular proteins such as MHC-class I and the IL-2 receptor. In addition, we observed a reduced percentage of CD4<superscript>+</superscript> T cells from infected individuals expressing PrPC, which was reflected by IFN type II but not IL-17 expression. Discussion: These results suggested that PrPC downregulation, linked to both HTLV-1 p12 and IFN-γ expression in CD4<superscript>+</superscript> cells, may play a role in the neuropathogenesis of HTLV-1 infection. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1664302X
- Database :
- Complementary Index
- Journal :
- Frontiers in Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 170708089
- Full Text :
- https://doi.org/10.3389/fmicb.2023.1175679