Back to Search Start Over

Criteria and Non-Criteria Antiphospholipid Antibodies in Antiphospholipid Syndrome: How Strong Are They Correlated?

Authors :
Caraiola, Simona
Voicu, Laura
Jurcut, Ciprian
Dima, Alina
Baicus, Cristian
Baicus, Anda
Cobilinschi, Claudia Oana
Ionescu, Razvan Adrian
Source :
Biomedicines; Aug2023, Vol. 11 Issue 8, p2192, 12p
Publication Year :
2023

Abstract

The place of non-criteria antiphospholipid antibodies (aPLs) in the diagnosis of antiphospholipid syndrome (APS) is still debatable. The aim of this research was to evaluate the correlations between the titres of non-criteria aPLs (anti-phosphatidylethanolamine (aPE), anti-phosphatidylserine (aPS), and anti-prothrombin (aPT) antibodies), and the ones of the already studied criteria aPLs (anti-cardiolipin (aCL) and anti-β2 glycoprotein I-aβ2GPI antibodies). Altogether, 72 APS (30 primary and 42 secondary) patients were included in our study. High correlation coefficients (rs) were found between aPS IgM and aCL IgM, overall (0.77, p < 0.01), as well as in the primary (0.81, p < 0.01), and secondary (0.75, p < 0.01) APS subgroups. Low or statistically insignificant correlations were observed between IgG/IgM isotypes of aPT and aCL, or aβ2GPI, in the entire study population, and when evaluating the subgroups. Therefore, moderate correlations were mainly identified between the tested non-criteria antibodies and the criteria ones, suggesting little added value for the use of the tested non-criteria aPLs, with the exception of aPT, which seems to have different kinetics and might be a promising APS diagnostic tool. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22279059
Volume :
11
Issue :
8
Database :
Complementary Index
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
170711935
Full Text :
https://doi.org/10.3390/biomedicines11082192