Synthesis of Sulfoximines through Selective Sulfur Alkylation of Sulfinamides Generated In Situ from β-Sulfoximine Esters.

Finally, -sulfoximine esters with alkyl substituents ( I tert i -butyl, cyclohexyl, butyl) were investigated under the standard reaction conditions and afforded the corresponding sulfoximine B 4h b - B j b in moderate yields (42-56%). Keywords: sulfoximines; S-alkylation; sulfinamides; sulfoximine esters EN sulfoximines S-alkylation sulfinamides sulfoximine esters 1829 1833 5 08/29/23 20230915 NES 230915 Graph The development of modern synthetic chemistry not only facilitates the construction of compound libraries, studies on structure-activity relationships, and developments of the synthesis process, but also considerably improves the rate of generation of small-molecule drugs and provides efficient support for the discovery of candidate drug compounds. Synthesis of Sulfoximines through Selective Sulfur Alkylation of Sulfinamides Generated In Situ from -Sulfoximine Esters The reaction then proceeds smoothly through a selective S-alkylation, rather than an N-alkylation, with readily available alkyl bromides to give the corresponding sulfoximines in reasonable yields (Scheme 1c). [Extracted from the article]