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Thermodynamic and mechanistic analysis of the functional properties of dengue virus NS3 helicase.

Authors :
Incicco, J. Jeremías
Cababie, Leila A.
Sarto, Carolina
Adler, Natalia S.
Amrein, Fernando
Mikkelsen, Evelyn
Arrar, Mehrnoosh
Kaufman, Sergio B.
Source :
Biophysical Reviews; Aug2023, Vol. 15 Issue 4, p591-600, 10p
Publication Year :
2023

Abstract

The Dengue Virus (DENV) non-structural protein 3 (NS3) is a multi-functional protein critical in the viral life cycle. The DENV NS3 is comprised of a serine protease domain and a helicase domain. The helicase domain itself acts as a molecular motor, either translocating in a unidirectional manner along single-stranded RNA or unwinding double-stranded RNA, processes fueled by the hydrolysis of nucleoside triphosphates. In this brief review, we summarize our contributions and ongoing efforts to uncover the thermodynamic and mechanistic functional properties of the DENV NS3 as an NTPase and helicase. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18672450
Volume :
15
Issue :
4
Database :
Complementary Index
Journal :
Biophysical Reviews
Publication Type :
Academic Journal
Accession number :
171387485
Full Text :
https://doi.org/10.1007/s12551-023-01101-5