Effect ofβ radiation on TGF-β1 and bFGF expression in hyperplastic prostatic tissues.

To investigate the transforming growth factorβ1 (TGF-β1) and basic fibroblast growth factor (bFGF) expressions in benign prostatic hyperplasia (BPH) and the effect ofβ-radiation.TGF-β1 and bFGF expression was studied by means of an immunohistochemical method in nine normal prostatic (NP) tissues, 15 hyperplastic prostatic tissues and 35 hyperplastic prostatic tissues treated with⁹⁰Sr/⁹⁰Y.The TGF-β1 expression in the epithelium and stroma of normal prostatic tissues was 68.2 %± 10.5 % and 29.7 %± 4.6 %, respectively, while it was 64.8 %± 9.3 % and 28.6 %± 4.1 %, respectively, in hyperplastic prostatic tissues. Compared with the controls, TGF-β1 expression in the epithelia and stroma of BPH treated with⁹⁰Sr/⁹⁰Y increased significantly (P<0.01). The bFGF expression in epithelia and stroma of normal prostatic tissues was 17.4 %± 3.7 % and 42.5 %± 6.8 %, respectively, and was 46.3 %± 8.2 % and 73.2 %± 12.1 %, respectivley, in hyperplastic prostatic tissues. Compared with the controls, expressions of bFGF in the epithelia and stroma of BPH treated with a⁹⁰Sr/⁹⁰Y prostatic hyperplasia applicator decreased significantly (P<0.01).Exposure ofβ-rays had noticeable effects on BPH tissues, enhancing TGF-β1 expression and inhibiting bFGF expression.(Asian J Androl 2005 Mar; 7: 49–54) [ABSTRACT FROM AUTHOR]