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COVID-19 vaccination is associated with enhanced efficacy of anti-PD-(L)1 immunotherapy in advanced NSCLC patients: a real-world study.
- Source :
- Infectious Agents & Cancer; 9/7/2023, Vol. 18 Issue 1, p1-11, 11p
- Publication Year :
- 2023
-
Abstract
- Background: Coronavirus disease 2019 (COVID-19) vaccine has played a major role in ending the pandemic. However, little is known about the influence of COVID-19 vaccine on the efficacy of immunotherapy in patients with non-small cell lung cancer (NSCLC). Objectives: The goal of this study is to explore whether COVID-19 vaccine impacts the efficacy of immune checkpoint inhibitors (ICIs) in NSCLC patients. Methods: We retrospectively analyzed the survival data of ICI-treated 104 patients with stage III–IV NSCLC, who either received COVID-19 vaccination (n = 25) or no vaccination (n = 79). The potential risk factors, in particular roles of COVID-19 vaccination in the efficacy of ICIs in these patients, were evaluated. Results: Our results showed significantly improved ORR (28.0% vs. 11.39%, p = 0.05) and DCR (88.0% vs. 54.43%, p = 0.005) in the COVID-19 vaccinated group compared with the non-vaccinated group. Regarding the long-term survival benefits, COVID-19 vaccine showed profound influence both on the PFS (HR = 0.16, p = 0.021) and OS (HR = 0.168, p = 0.019) in patients with NSCLC under ICIs treatment. The PFS (p < 0.001) or OS (p < 0.001) was significantly improved in the COVID-19 vaccinated group, compared with the non-vaccinated group. Moreover, CD4 T cell (p = 0.047) level was higher in the COVID-19 vaccinated group than in the non-vaccinated group. Conclusions: COVID-19 vaccination enhances anti-PD-1 immunotherapy efficacy in patients with stage III–IV NSCLC, suggesting that COVID-19 vaccination may provide additional benefit to NSCLC patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- LUNG cancer
DRUG efficacy
IMMUNE checkpoint inhibitors
COVID-19 vaccines
RETROSPECTIVE studies
ACQUISITION of data
TUMOR classification
CANCER patients
MEDICAL records
DESCRIPTIVE statistics
RESEARCH funding
VACCINATION status
PROGRESSION-free survival
T cells
OVERALL survival
PHARMACODYNAMICS
EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 17509378
- Volume :
- 18
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Infectious Agents & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 171806201
- Full Text :
- https://doi.org/10.1186/s13027-023-00526-7