Back to Search
Start Over
Risk Factors for Immune Checkpoint Inhibitor Immunotherapy Toxicity Among Older Adults with Cancer.
- Source :
- Oncologist; Aug2023, Vol. 28 Issue 8, pe625-e632, 8p, 3 Charts
- Publication Year :
- 2023
-
Abstract
- Objectives Immune checkpoint inhibitor immunotherapy (IO) is revolutionizing cancer care but can lead to significant toxicity. This study seeks to describe potential risk factors for immune-related adverse events (irAEs) specifically among older adults. Materials and Methods This was a retrospective study at a single academic comprehensive cancer center based on chart review data abstracted by physicians. For patients aged ≥70 years, frequency, type, and grade of irAEs and their association with baseline patient demographics, comorbidities, mobility, and functional status were characterized using bivariate analysis. Based on those results, multivariable logistic regressions were constructed to model the association between these characteristics with any grade and grade 3 or higher irAEs. Results Data were analyzed for 238 patients aged ≥70 years who received IO for mostly (≥90%) advanced cancer between 2011 and 2018. Thirty-nine percent of older adults experienced an irAE and 13% experienced one that was grade 3 or higher. In the multivariable analysis, depression was associated with an increased incidence of any grade irAE, while decreased life-space mobility was associated with an increased incidence of grade ≥3 irAEs. Conclusion Most characteristics of special interest among older adults, include fall risk, weight loss, cognitive limitations, and hearing loss, were not associated with irAEs in our study. However, decreased life-space mobility and depression are potential risk factors for IO toxicity among older adults with advanced cancer. Interventions designed to evaluate and mitigate modifiable risk factors for treatment-related toxicity are needed, and the results of this study may be useful for guiding those efforts. [ABSTRACT FROM AUTHOR]
- Subjects :
- STATISTICS
IMMUNE checkpoint inhibitors
ACADEMIC medical centers
FUNCTIONAL status
MULTIPLE regression analysis
MULTIVARIATE analysis
GERIATRICS
RETROSPECTIVE studies
ACQUISITION of data
RISK assessment
CANCER patients
MEDICAL records
MENTAL depression
ACCIDENTAL falls
RESEARCH funding
TUMORS
IMMUNOTHERAPY
DRUG toxicity
COMORBIDITY
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 10837159
- Volume :
- 28
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Oncologist
- Publication Type :
- Academic Journal
- Accession number :
- 171903949
- Full Text :
- https://doi.org/10.1093/oncolo/oyad097