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Strong Inhibition of Ice Growth by Biomimetic Crowding Coacervates.
- Source :
- Angewandte Chemie International Edition; 9/18/2023, Vol. 62 Issue 38, p1-7, 7p
- Publication Year :
- 2023
-
Abstract
- The freezing of biological fluids is intensively studied but remains elusive as it is affected not only by the various components but also by the crowding nature of the biological fluids. Herein, we constructed spherical crowders, fibrous crowders, and coacervates by various components ranging from surfactants to polymers and proteins, to mimic three typical crowders in biological fluids, i.e. globular proteins, fibrous networks, and condensates of biomolecules. It is elucidated that the three crowders exhibit low, moderate, and strong ice growth inhibition activity, respectively, resulting from their different abilities in slowing down water dynamics. Intriguingly, the coacervate consisting of molecules without obvious ice growth inhibition activity strongly inhibits ice growth, which is firstly employed as a highly‐potent cryoprotectant. This work provides new insights into the survival of freezing‐tolerant organisms and opens an avenue for the design of ice‐controlling materials. [ABSTRACT FROM AUTHOR]
- Subjects :
- GLOBULAR proteins
BIOMOLECULES
RECRYSTALLIZATION (Metallurgy)
SURFACE active agents
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 62
- Issue :
- 38
- Database :
- Complementary Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 171961391
- Full Text :
- https://doi.org/10.1002/anie.202311047