Back to Search
Start Over
Multigram‑scale synthesis of BTK inhibitor BIIB068.
- Source :
- Chemical Papers; Nov2023, Vol. 77 Issue 11, p6471-6481, 11p
- Publication Year :
- 2023
-
Abstract
- This paper describes the development of a relatively feasible, economic, and safe method for the multigram-scale synthesis of BIIB068, an efficient reversible BTK inhibitor. The new process is highlighted by an economical construction of a 2-amino-4 substituted pyrimidine employing a simple nucleophilic substitution reaction and a green reduction of the cyano group. The developed process provided an overall yield of 32%, with an HPLC purity of 99%. The structure of BIIB068 was confirmed by MS, IR, <superscript>1</superscript>H-NMR, and <superscript>13</superscript>C-NMR, and the structures of some intermediates were confirmed by MS and <superscript>1</superscript>H-NMR. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03666352
- Volume :
- 77
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Chemical Papers
- Publication Type :
- Academic Journal
- Accession number :
- 172312744
- Full Text :
- https://doi.org/10.1007/s11696-023-02951-9