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A Key Role of CD8+ T Cells in Controlling of Tuberculosis Infection.
- Source :
- Diagnostics (2075-4418); Sep2023, Vol. 13 Issue 18, p2961, 15p
- Publication Year :
- 2023
-
Abstract
- The main role in the control of tuberculosis infection is played by macrophages and Th1 and CD8+ T cells. The study aimed to identify the most diagnostically significant CD8+ T cell subsets in tuberculosis patients. Methods: Peripheral blood samples from patients with clinical, radiological, and bacteriologically confirmed pulmonary tuberculosis (TB, n = 32) and healthy subjects (HC, n = 31) were collected and analyzed using 10-color flow cytometry. Results: The frequency of the EM4 CD3+CD8+ cells was reduced in the peripheral blood of patients with pulmonary tuberculosis, while the relative and absolute number of EM1 CD3+CD8+ cells increased compared to the control group. CD57 expression was reduced in patients with pulmonary tuberculosis on EM1, EM2, and pE1 CD3+CD8+ cells, whereas the EM3 cells had a high level of CD57 expression. The relative and absolute number of Tc2 (CCR6–CXCR3–) cells in peripheral blood in patients with pulmonary tuberculosis was increased, while the frequency of Tc1 (CCR6–CXCR3+) was decreased, compared to healthy donors. Conclusions: Patients with pulmonary tuberculosis have an abnormal CD3+CD8+ cell profile and demonstrate their impaired maturation and functional activity. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
TUBERCULOSIS
CD8 antigen
TUBERCULOSIS patients
INFECTION control
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 13
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- Diagnostics (2075-4418)
- Publication Type :
- Academic Journal
- Accession number :
- 172416337
- Full Text :
- https://doi.org/10.3390/diagnostics13182961