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Metal-Organic Frameworks: Versatile Platforms for Biomedical Innovations.

Authors :
Păun, Cătălin
Motelică, Ludmila
Ficai, Denisa
Ficai, Anton
Andronescu, Ecaterina
Source :
Materials (1996-1944); Sep2023, Vol. 16 Issue 18, p6143, 20p
Publication Year :
2023

Abstract

This review article explores the multiple applications and potential of metal-organic frameworks (MOFs) in the biomedical field. With their highly versatile and tunable properties, MOFs present many possibilities, including drug delivery, biomolecule recognition, biosensors, and immunotherapy. Their crystal structure allows precise tuning, with the ligand typology and metal geometry playing critical roles. MOFs' ability to encapsulate drugs and exhibit pH-triggered release makes them ideal candidates for precision medicine, including cancer treatment. They are also potential gene carriers for genetic disorders and have been used in biosensors and as contrast agents for magnetic resonance imaging. Despite the complexities encountered in modulating properties and interactions with biological systems, further research on MOFs is imperative. The primary focus of this review is to provide a comprehensive examination of MOFs in these applications, highlighting the current achievements and complexities encountered. Such efforts will uncover their untapped potential in creating innovative tools for biomedical applications, emphasizing the need to invest in the continued exploration of this promising field. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19961944
Volume :
16
Issue :
18
Database :
Complementary Index
Journal :
Materials (1996-1944)
Publication Type :
Academic Journal
Accession number :
172418048
Full Text :
https://doi.org/10.3390/ma16186143