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99mTc-Tilmanocept performance for sentinel node mapping in breast cancer, melanoma, and head and neck cancer: a systematic review and meta-analysis from a European expert panel.

Authors :
Rovera, Guido
de Koster, Elizabeth J.
Rufini, Vittoria
Zollino, Mariella
Zagaria, Luca
Giammarile, Francesco
Vidal-Sicart, Sergi
Valdés Olmos, Renato
Collarino, Angela
Source :
European Journal of Nuclear Medicine & Molecular Imaging; Sep2023, Vol. 50 Issue 11, p3375-3389, 15p, 1 Diagram, 3 Charts, 9 Graphs
Publication Year :
2023

Abstract

Purpose: Although multiple radiopharmaceuticals are currently available for sentinel node (SN) biopsy, <superscript>99m</superscript>Tc-tilmanocept is of particular interest due to its low molecular weight and specific binding capability for the mannose receptors of lymphatic reticuloendothelial cells. In the current systematic review and meta-analysis, we aimed to provide an update from a European expert panel on the performance of <superscript>99m</superscript>Tc-tilmanocept for SN biopsy. Methods: A systematic literature search of the PubMed/Medline and Embase databases was performed to identify studies on the use of <superscript>99m</superscript>Tc-tilmanocept for SN identification in oncological patients. The articles' methodological quality was assessed before inclusion. The pooled estimates of the pre-/intraoperative detection rates (DR; proportion of patients with ≥ 1 SN identified) and/or pN + sensitivity (SN + /pN + patients ratio), with 95% confidence intervals (CIs), were calculated for breast cancer, melanoma, and head and neck cancer. Results: Twenty-four articles were included in the systematic review, and twenty-one provided data for the meta-analysis. According to data availability, the <superscript>99m</superscript>Tc-tilmanocept-estimated pooled preoperative and intraoperative DRs were 0.94 (95%CI, 0.88–1.01) and 0.99 (0.98–1.00) for breast cancer, 0.98 (0.96–0.99) and 1.00 (0.99–1.00) for melanoma, and 0.97 (0.93–1.02) and 0.99 (0.96–1.01) for head and neck carcinoma. Finally, the pooled sensitivity for nodal metastasis in melanoma was 0.97 (95% CI, 0.92–1.03). Conclusion: <superscript>99m</superscript>Tc-tilmanocept is a promising radiotracer for SN mapping in patients with breast cancer, melanoma, or head and neck cancer. We strongly believe that multicenter trials are still needed to assess if <superscript>99m</superscript>Tc-tilmanocept is superior to other radiotracers used in clinical routine. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16197070
Volume :
50
Issue :
11
Database :
Complementary Index
Journal :
European Journal of Nuclear Medicine & Molecular Imaging
Publication Type :
Academic Journal
Accession number :
172445105
Full Text :
https://doi.org/10.1007/s00259-023-06290-5