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CD4 + T Cell Responses to Toxoplasma gondii Are a Double-Edged Sword.
- Source :
- Vaccines; Sep2023, Vol. 11 Issue 9, p1485, 18p
- Publication Year :
- 2023
-
Abstract
- CD4<superscript>+</superscript> T cells have been found to play critical roles in the control of both acute and chronic Toxoplasma infection. Previous studies identified a protective role for the Toxoplasma CD4<superscript>+</superscript> T cell-eliciting peptide AS15 (AVEIHRPVPGTAPPS) in C57BL/6J mice. Herein, we found that immunizing mice with AS15 combined with GLA-SE, a TLR-4 agonist in emulsion adjuvant, can be either helpful in protecting male and female mice at early stages against Type I and Type II Toxoplasma parasites or harmful (lethal with intestinal, hepatic, and spleen pathology associated with a storm of IL6). Introducing the universal CD4<superscript>+</superscript> T cell epitope PADRE abrogates the harmful phenotype of AS15. Our findings demonstrate quantitative and qualitative features of an effective Toxoplasma-specific CD4<superscript>+</superscript> T cell response that should be considered in testing next-generation vaccines against toxoplasmosis. Our results also are cautionary that individual vaccine constituents can cause severe harm depending on the company they keep. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
TOXOPLASMA gondii
CD4 antigen
VACCINE trials
PEPTIDES
Subjects
Details
- Language :
- English
- ISSN :
- 2076393X
- Volume :
- 11
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Vaccines
- Publication Type :
- Academic Journal
- Accession number :
- 172752138
- Full Text :
- https://doi.org/10.3390/vaccines11091485