Terpyridine-Containing 5-(2-Pyridylmethylene)-2-thioimidazolones and Their Coordination Compounds with Copper(II) Chloride: Synthesis and Cytotoxicity.

Methods for the synthesis of new ditopic organic ligands containing coordinating fragments of two types, terpyridine and thiohydantoin, have been developed. The complex formation reactions of the synthesized ligands with copper(II) chloride were studied. As a result, two types of coordination compounds were isolated and characterized by electron spectroscopy, elemental analysis, and cyclic voltammetry: copper(I,II) bis-ligand tetranuclear mixed-valent complexes and a monoligand binuclear complex containing two copper(II) ions. The cytotoxic activity of the obtained coordination compounds with respect to the MCF7, A549, and HEK293 cell lines was studied. [ABSTRACT FROM AUTHOR]