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Expression of CD105 but not of E-cadherin is associated with malignancy recurrence and disease-free interval in laryngeal cancer in men.
- Source :
- Folia Histochemica et Cytobiologica; 2023, Vol. 61 Issue 3, p183-192, 10p
- Publication Year :
- 2023
-
Abstract
- Introduction. In this study we analyzed CD105 (endoglin) and E-cadherin expression in laryngeal squamous cell carcinoma (LSCC) to evaluate their clinicopathologic significance. Material and methods. Expression of CD105 and E-cadherin was examined immunohistochemically using paraffin- -embedded archival tissues of 72 (35 glottic and 37 supraglottic) previously untreated LSCC male patients. The mean value of the positively-stained microvessels for CD105 counted in four hot spots for each case was used as the final intratumoralmicrovessel density (MVD). A staining score of E-cadherin was calculated based on the percentage of cells stained (0--100%). Results. MVD was significantly higher in patients with advanced TNM stage (P = 0.004) and younger than 65 (P = 0.008). Nodal metastases were more frequent in the cases with low E-cadherin expression (P = 0.000). Tumor recurrence was associated with advanced TNM stage (P = 0.035) and high MVD (P = 0.002). A high MVD was an independent predictor of malignancy recurrence (P = 0.021). The log-rank test showed a significant difference in the disease-free interval in patients stratified according to the MVD value (P = 0.016). Spearman's rank correlation test did not show a significant correlation between E-cadherin and CD105 expression. Conclusions. CD105-assessed MVD and expression of E-cadherin are promising prognostic factors for the outcome of patients with LSCC. Increased expression of CD105 could help predict patients with an increased risk of developing loco-regional recurrence after surgical treatment. Decreased E-cadherin expression is a potential predictor of lymph node metastases. (Folia Histochemica et Cytobiologica 2023, Vol. 61, No. 3, 183--192) [ABSTRACT FROM AUTHOR]
- Subjects :
- STATISTICS
GENETIC mutation
MEN'S health
NEOVASCULARIZATION inhibitors
IMMUNOHISTOCHEMISTRY
LOG-rank test
LARYNGEAL tumors
CANCER relapse
METASTASIS
RETROSPECTIVE studies
ENDOGLIN
GENE expression
TREATMENT effectiveness
GLYCOPROTEINS
DESCRIPTIVE statistics
TUMOR markers
DATA analysis
SQUAMOUS cell carcinoma
PARAFFIN wax
Subjects
Details
- Language :
- English
- ISSN :
- 02398508
- Volume :
- 61
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Folia Histochemica et Cytobiologica
- Publication Type :
- Academic Journal
- Accession number :
- 172926880
- Full Text :
- https://doi.org/10.5603/fhc.97035