Back to Search
Start Over
Association of periodontitis with cognitive decline and its progression: Contribution of blood‐based biomarkers of Alzheimer's disease to this relationship.
- Source :
- Journal of Clinical Periodontology; Nov2023, Vol. 50 Issue 11, p1444-1454, 11p
- Publication Year :
- 2023
-
Abstract
- Aim: To assess whether periodontitis is associated with cognitive decline and its progression as well as with certain blood‐based markers of Alzheimer's disease. Materials and Methods: Data from a 2‐year follow‐up prospective cohort study (n = 101) was analysed. Participants with a previous history of hypertension and aged ≥60 years were included in the analysis. All of them received a full‐mouth periodontal examination and cognitive function assessments (Addenbrooke's Cognitive Examination (ACE) and Mini‐Mental State Examination [MMSE]). Plasma levels of amyloid beta (Aβ)1‐40, Aβ1‐42, phosphorylated and total Tau (p‐Tau and t‐Tau) were determined at baseline, 12 and 24 months. Results: Periodontitis was associated with poor cognitive performance (MMSE: β = −1.5 [0.6]) and progression of cognitive impairment (hazard ratio [HR] = 1.8; 95% confidence interval: 1.0–3.1). Subjects with periodontitis showed greater baseline levels of p‐Tau (1.6 [0.7] vs. 1.2 [0.2] pg/mL, p <.001) and Aβ1‐40 (242.1 [77.3] vs. 208.2 [73.8] pg/mL, p =.036) compared with those without periodontitis. Concentrations of the latter protein also increased over time only in the periodontitis group (p =.005). Conclusions: Periodontitis is associated with cognitive decline and its progression in elderly patients with a previous history of hypertension. Overexpression of p‐Tau and Aβ1‐40 may play a role in this association. [ABSTRACT FROM AUTHOR]
- Subjects :
- DISEASE progression
BIOMARKERS
HYPERTENSION
ALZHEIMER'S disease
CONFIDENCE intervals
PERIODONTITIS
TAU proteins
REGRESSION analysis
AMYLOID beta-protein precursor
NEUROPSYCHOLOGICAL tests
PSYCHOLOGICAL tests
GENE expression
AMBULATORY blood pressure monitoring
DESCRIPTIVE statistics
RESEARCH funding
COGNITION disorders in old age
LOGISTIC regression analysis
SECONDARY analysis
PROPORTIONAL hazards models
DISEASE complications
OLD age
Subjects
Details
- Language :
- English
- ISSN :
- 03036979
- Volume :
- 50
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 172959781
- Full Text :
- https://doi.org/10.1111/jcpe.13861