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Predictive Potential of Biomarkers of Intestinal Barrier Function for Therapeutic Management with Teduglutide in Patients with Short Bowel Syndrome.

Authors :
Büttner, Janine
Blüthner, Elisabeth
Greif, Sophie
Kühl, Anja
Elezkurtaj, Sefer
Ulrich, Jan
Maasberg, Sebastian
Jochum, Christoph
Tacke, Frank
Pape, Ulrich-Frank
Source :
Nutrients; Oct2023, Vol. 15 Issue 19, p4220, 27p
Publication Year :
2023

Abstract

Introduction: The human intestinal tract reacts to extensive resection with spontaneous intestinal adaptation. We analyzed whether gene expression analyses or intestinal permeability (IP) testing could provide biomarkers to describe regulation mechanisms in the intestinal barrier in short bowel syndrome (SBS) patients during adaptive response or treatment with the glucagon-like peptide-2 analog teduglutide. Methods: Relevant regions of the GLP-2 receptor gene were sequenced. Gene expression analyses and immunohistochemistry were performed from mucosal biopsies. IP was assessed using a carbohydrate oral ingestion test. Results: The study includes 59 SBS patients and 19 controls. Increases in gene expression with teduglutide were received for sucrase-isomaltase, sodium/glucose cotransporter 1, and calcium/calmodulin serine protein kinase. Mannitol recovery was decreased in SBS but elevated with teduglutide (Δ 40%), showed a positive correlation with remnant small bowel and an inverse correlation with parenteral support. Conclusions: Biomarkers predicting clinical and functional features in human SBS are very limited. Altered specific gene expression was shown for genes involved in nutrient transport but not for genes controlling tight junctions. However, mannitol recovery proved useful in describing the absorptive capacity of the gut during adaptation and treatment with teduglutide. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20726643
Volume :
15
Issue :
19
Database :
Complementary Index
Journal :
Nutrients
Publication Type :
Academic Journal
Accession number :
172983038
Full Text :
https://doi.org/10.3390/nu15194220