Cu/photoredox-catalyzed decarboxylative radical C(sp3)-C(sp3) cross-coupling reactions.

A radical decarboxylative C(sp³)-C(sp³) cross-coupling of NHPI esters and cyclopropanols was developed by combining photocatalysis and copper catalysis, which presents the efficient access to β-benzyl ketones in excellent yields. Terpyridin-4′-one used as the ligand is vital for the reaction, which could facilitate the capture of benzylic radicals by alkyl-copper species generated from copper-catalyzed ring-opening of cyclopropanols. The reaction exhibited broad substrate scope and wide functional group compatibility, providing an alternative approach for C(sp³)-C(sp³) bond formation. [ABSTRACT FROM AUTHOR]