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Somatostatin receptor subtype expression and radiomics from DWI-MRI represent SUV of [68Ga]Ga-DOTATOC PET in patients with meningioma.
- Source :
- Journal of Neuro-Oncology; Sep2023, Vol. 164 Issue 3, p711-720, 10p
- Publication Year :
- 2023
-
Abstract
- Objective: This retrospective study aimed to analyse the correlation between somatostatin receptor subtypes (SSTR 1–5) and maximum standardized uptake value (SUV<subscript>max</subscript>) in meningioma patients using Gallium-68 DOTA-D-Phe1-Tyr3-octreotide Positron Emission Tomography ([68Ga]Ga-DOTATOC PET). Secondly, we developed a radiomic model based on apparent diffusion coefficient (ADC) maps derived from diffusion weighted magnetic resonance images (DWI MRI) to reproduce SUV<subscript>max</subscript>. Method: The study included 51 patients who underwent MRI and [68Ga]Ga-DOTATOC PET before meningioma surgery. SUV<subscript>max</subscript> values were quantified from PET images and tumour areas were segmented on post-contrast T1-weighted MRI and mapped to ADC maps. A total of 1940 radiomic features were extracted from the tumour area on each ADC map. A random forest regression model was trained to predict SUV<subscript>max</subscript> and the model's performance was evaluated using repeated nested cross-validation. The expression of SSTR subtypes was quantified in 18 surgical specimens and compared to SUV<subscript>max</subscript> values. Results: The random forest regression model successfully predicted SUV<subscript>max</subscript> values with a significant correlation observed in all 100 repeats (p < 0.05). The mean Pearson's r was 0.42 ± 0.07 SD, and the root mean square error (RMSE) was 28.46 ± 0.16. SSTR subtypes 2A, 2B, and 5 showed significant correlations with SUV<subscript>max</subscript> values (p < 0.001, R2 = 0.669; p = 0.001, R2 = 0.393; and p = 0.012, R2 = 0.235, respectively). Conclusion: SSTR subtypes 2A, 2B, and 5 correlated significantly with SUV<subscript>max</subscript> in meningioma patients. The developed radiomic model based on ADC maps effectively reproduces SUV<subscript>max</subscript> using [68Ga]Ga-DOTATOC PET. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0167594X
- Volume :
- 164
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Neuro-Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 173152792
- Full Text :
- https://doi.org/10.1007/s11060-023-04414-3