Back to Search
Start Over
A pharmacological evaluation of ethanol extract of alpinia calcarata rhizome for anti-oxidant, anti-inflammatory and anti-asthmatic properties.
- Source :
- Journal of Advanced Zoology; 2023 Supplement, Vol. 44, p917-928, 12p
- Publication Year :
- 2023
-
Abstract
- Alpinia calcarata rhizome ethanolic extract was tested for anti-asthmatic, antioxidant, and anti-inflammatory properties. Adaptogens normalize leukocytosis after milk consumption. Eosinophils are necessary for allergic illness development. The plant extract significantly reduced allergic asthmarelated eosinophil cell count compared to the control group. Eosinophil count decreases cell recruitment and IL-4, IL-5, and IL-13, which affect cell count. Studies on milk-induced leukocytosis and eosinophils verified the plant extract's anti-asthmatic capabilities. In guinea pigs, goats, horses, dogs, and humans, histamine contracts trachea and bronchial muscles. Tracheas in guinea pigs test asthma drugs. The isolated guinea pig trachea contracts dosedependently after H1 receptor stimulation. Alpinia calcarata reduced histamine-induced trachea constriction in solitary guinea pigs, proving its anti-asthmatic and H1 receptor antagonist capabilities. Hydrogen peroxide scavenging and reduction were used to test antioxidants. A hydrogen peroxide-scavenging Alpinia calcarata rhizome ethanol extract. Hydrogen peroxide scavenged less than ascorbic acid. Increasing Alpinia calcarata rhizome ethanolic extract dramatically lowered power. In vitro, ethanolic Alpinia calcarata rhizome extract stabilized rabbit red blood cell membranes and prevented protein denaturation. The ethanolic Alpinia calcarata rhizome extract was anti-asthmatic. Antioxidant and anti-inflammatory characteristics aid the plant's anti-astatic effects. Most asthma medications are steroidal. The phytochemical study identified steroids and flavonoids. Chemical moieties may make the plant anti-asthmatic. The findings support the conventional and advise more anti-asthmatic active component study. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALPINIA
ANTIOXIDANTS
PLANT extracts
ANTI-inflammatory agents
ANTIASTHMATIC agents
Subjects
Details
- Language :
- English
- ISSN :
- 02537214
- Volume :
- 44
- Database :
- Complementary Index
- Journal :
- Journal of Advanced Zoology
- Publication Type :
- Academic Journal
- Accession number :
- 173169830