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Autophagy promotes MHC class II presentation of peptides from intracellular source proteins.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 5/31/2005, Vol. 102 Issue 22, p7922-7927, 6p
- Publication Year :
- 2005
-
Abstract
- MHC-peptide complexes mediate key functions in adaptive immunity. In a classical view, MHC-I molecules present peptides from intracellular source proteins, whereas MHC-II molecules present antigenic peptides from exogenous and membrane proteins. Nevertheless, substantial crosstalk between these two pathways has been observed. We investigated the influence of autophagy on the MHC-II ligandome and demonstrated that peptide presentation is altered considerably upon induction of autophagy. The presentation of peptides from intracellular and lysosomal source proteins was strongly increased on MHC-II in contrast with peptides from membrane and secreted proteins. In addition, autophagy influenced the MHC-II antigen-processing machinery. Our study illustrates a profound influence of autophagy on the class II peptide repertoire and suggests that this finding has implications for the regulation of CD4<superscript>+</superscript> T cell-mediated processes. [ABSTRACT FROM AUTHOR]
- Subjects :
- PEPTIDES
IMMUNITY
PROTEINS
BIOMOLECULES
T cells
BIOLOGICAL membranes
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 102
- Issue :
- 22
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 17320118
- Full Text :
- https://doi.org/10.1073/pnas.0501190102