Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility. (Updated October 12, 2023).

According to a preprint abstract, researchers have discovered a subpopulation of neurons in the hypothalamus that play a role in respiration and cardiovascular function. By using chemo- and optogenetic tools, the researchers were able to selectively alter the activity of these neurons and their terminal endings in the periaqueductal gray. The results showed that activation of these neurons led to changes in respiration, immobility, and bradycardia. This research has not yet undergone peer review. [Extracted from the article]