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Challenges and Strategies for Optimizing Corrosion and Biodegradation Stability of Biomedical Micro‐ and Nanoswimmers: A Review.

Authors :
Rahimi, Ehsan
Sanchis‐Gual, Roger
Chen, Xiangzhong
Imani, Amin
Gonzalez‐Garcia, Yaiza
Asselin, Edouard
Mol, Arjan
Fedrizzi, Lorenzo
Pané, Salvador
Lekka, Maria
Source :
Advanced Functional Materials; 10/25/2023, Vol. 33 Issue 44, p1-22, 22p
Publication Year :
2023

Abstract

The last two decades have witnessed the emergence of micro‐ and nanoswimmers (MNSs). Researchers have invested significant efforts in engineering motile micro‐ and nanodevices to address current limitations in minimally invasive medicine. MNSs can move through complex fluid media by using chemical fuels or external energy sources such as magnetic fields, ultrasound, or light. Despite significant advancements in their locomotion and functionalities, the gradual deterioration of MNSs in human physiological media is often overlooked. Corrosion and biodegradation caused by chemical reactions with surrounding medium and the activity of biological agents can significantly affect their chemical stability and functional properties during their lifetime performance. It is therefore essential to understand the degradation mechanisms and factors that influence them to design ideal biomedical MNSs that are affordable, highly efficient, and sufficiently resistant to degradation (at least during their service time). This review summarizes recent studies that delve into the physicochemical characteristics and complex environmental factors affecting the corrosion and biodegradation of MNSs, with a focus on metal‐based devices. Additionally, different strategies are discussed to enhance and/or optimize their stability. Conversely, controlled degradation of non‐toxic MNSs can be highly advantageous for numerous biomedical applications, allowing for less invasive, safer, and more efficient treatments. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1616301X
Volume :
33
Issue :
44
Database :
Complementary Index
Journal :
Advanced Functional Materials
Publication Type :
Academic Journal
Accession number :
173231139
Full Text :
https://doi.org/10.1002/adfm.202210345