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Enzymatic reversion of Pt(II) nucleophilicity through charge dumping: the case of Pt(CN)42−.
- Source :
- Chemical Communications; 11/7/2023, Vol. 59 Issue 86, p12847-12850, 4p
- Publication Year :
- 2023
-
Abstract
- Combining computations and X-ray structure analysis we have demonstrated that [Pt(CN<subscript>4</subscript>)]<superscript>2−</superscript> can behave as a Lewis acid inside an enzyme's cavity. The nature of a counterintuitive contact found between a catalytically active GLN residue belonging to a mitochondrial synthase and the Pt(II) center was investigated by combining molecular dynamics and quantum mechanics calculations. Results confirm the electron acceptor role of [Pt(CN<subscript>4</subscript>)]<superscript>2−</superscript>, serving as an inspiration for the design of biomolecular cages able to tweak the nucleophilic/electrophilic character of an organometallic compound. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 59
- Issue :
- 86
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 173237911
- Full Text :
- https://doi.org/10.1039/d3cc03816e