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Differences in Cerebral Metabolism between Moderate- and High-Severity Groups of Patients with Out-of-Hospital Cardiac Arrest Undergoing Target Temperature Management.
- Source :
- Brain Sciences (2076-3425); Oct2023, Vol. 13 Issue 10, p1373, 10p
- Publication Year :
- 2023
-
Abstract
- The aim of this study was to investigate the differences in cerebral metabolism and the prognostic value of cerebrospinal fluid (CSF) lactate 24 h after the return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest (OHCA). CSF lactate and pyruvate levels were measured immediately and every 2 h for 24 h after the ROSC. The distribution of cerebral mitochondrial dysfunction (MD) and cerebral ischemia was also evaluated. In the moderate-severity group, the absence of cerebral MD or ischemia was observed in six patients (40.0%) immediately after ROSC and in nine patients (60.0%) 24 h after the ROSC. In the high-severity group, the absence of cerebral MD or ischemia was observed in four patients (30.8%) immediately after ROSC and in three patients (23.1%) 24 h after the ROSC. The distribution of cerebral metabolism over time varied depending on the severity of the OHCA. The predictive value of CSF lactate levels for a poor neurological prognosis was better for patients in the moderate-severity group than for the overall patient cohort. Therefore, the severity in the patients with OHCA should be considered when studying cerebral metabolism or using CSF lactate as a prognostic tool. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 20763425
- Volume :
- 13
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Brain Sciences (2076-3425)
- Publication Type :
- Academic Journal
- Accession number :
- 173268757
- Full Text :
- https://doi.org/10.3390/brainsci13101373