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Differences in Cerebral Metabolism between Moderate- and High-Severity Groups of Patients with Out-of-Hospital Cardiac Arrest Undergoing Target Temperature Management.

Authors :
You, Yeonho
Kang, Changshin
Jeong, Wonjoon
Ahn, Hong Joon
Park, Jung Soo
Min, Jin Hong
In, Yong Nam
Lee, Jae Kwang
Jeon, So Young
Source :
Brain Sciences (2076-3425); Oct2023, Vol. 13 Issue 10, p1373, 10p
Publication Year :
2023

Abstract

The aim of this study was to investigate the differences in cerebral metabolism and the prognostic value of cerebrospinal fluid (CSF) lactate 24 h after the return of spontaneous circulation (ROSC) in patients with out-of-hospital cardiac arrest (OHCA). CSF lactate and pyruvate levels were measured immediately and every 2 h for 24 h after the ROSC. The distribution of cerebral mitochondrial dysfunction (MD) and cerebral ischemia was also evaluated. In the moderate-severity group, the absence of cerebral MD or ischemia was observed in six patients (40.0%) immediately after ROSC and in nine patients (60.0%) 24 h after the ROSC. In the high-severity group, the absence of cerebral MD or ischemia was observed in four patients (30.8%) immediately after ROSC and in three patients (23.1%) 24 h after the ROSC. The distribution of cerebral metabolism over time varied depending on the severity of the OHCA. The predictive value of CSF lactate levels for a poor neurological prognosis was better for patients in the moderate-severity group than for the overall patient cohort. Therefore, the severity in the patients with OHCA should be considered when studying cerebral metabolism or using CSF lactate as a prognostic tool. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20763425
Volume :
13
Issue :
10
Database :
Complementary Index
Journal :
Brain Sciences (2076-3425)
Publication Type :
Academic Journal
Accession number :
173268757
Full Text :
https://doi.org/10.3390/brainsci13101373