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Increased glymphatic system activity in migraine chronification by diffusion tensor image analysis along the perivascular space.
- Source :
- Journal of Headache & Pain; 11/6/2023, Vol. 24 Issue 1, p1-10, 10p
- Publication Year :
- 2023
-
Abstract
- Background: Preliminary evidence suggests that several headache disorders may be associated with glymphatic dysfunction. However, no studies have been conducted to examine the glymphatic activity in migraine chronification. Purposes: To investigate the glymphatic activity of migraine chronification in patients with episodic migraine (EM) and chronic migraine (CM) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) method. Methods: In this cross-sectional study, patients with EM, CM, and healthy controls (HCs) were included. All participants underwent a standard brain magnetic resonance imaging (MRI) examination. Bilateral DTI-ALPS indexes were calculated for all participants and compared among EM, CM, and HC groups. Correlations between the DTI-ALPS index and clinical characteristics were analyzed. Results: A total of 32 patients with EM, 24 patients with CM, and 41 age- and sex-matched HCs were included in the analysis. Significant differences were found in the right DTI-ALPS index among the three groups (p = 0.011), with CM showing significantly higher values than EM (p = 0.033) and HCs (p = 0.015). The right DTI-ALPS index of CM group was significantly higher than the left DTI-ALPS index (p = 0.005). And the headache intensity was correlated to DTI-ALPS index both in the left hemisphere (r = 0.371, p = 0.011) and in the right hemisphere (r = 0.307, p = 0.038), but there were no correlations after Bonferroni correction. Conclusions: Glymphatic system activity is shown to be increased instead of impaired during migraine chronification. The mechanism behind this observation suggests that increased glymphatic activity is more likely to be a concomitant phenomenon of altered vascular reactivity associated with migraine pathophysiology rather than a risk factor of migraine chronification. [ABSTRACT FROM AUTHOR]
- Subjects :
- MIGRAINE diagnosis
BRAIN
CEREBRAL hemispheres
CHRONIC diseases
MIGRAINE
CROSS-sectional method
ONE-way analysis of variance
MAGNETIC resonance imaging
MANN Whitney U Test
COMPARATIVE studies
T-test (Statistics)
QUESTIONNAIRES
DESCRIPTIVE statistics
CHI-squared test
RESEARCH funding
DATA analysis software
LYMPHATICS
Subjects
Details
- Language :
- English
- ISSN :
- 11292369
- Volume :
- 24
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Headache & Pain
- Publication Type :
- Academic Journal
- Accession number :
- 173431915
- Full Text :
- https://doi.org/10.1186/s10194-023-01673-3