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Dendrobium officinale Polysaccharides Inhibit CDCA-Induced Gastric Intestinal Metaplasia through Activating NRF2/HO-1 and Modulating HNF4α/CDX2 Signaling Pathway.
- Source :
- Journal of Food Biochemistry; 10/20/2023, p1-11, 11p
- Publication Year :
- 2023
-
Abstract
- Bile reflux (BR) was considered to be an independent risk factor for the development of precancerous gastric lesions and GC. Dendrobium officinale polysaccharides (DOP) show a novel potential in preventing the progress of gastric cancer. However, the specific mechanism of DOP that causes such activities remains a mystery. This study aimed to investigate the effects of DOP on chenodeoxycholic acid (CDCA)-induced gastric intestinal metaplasia and explore the underlying mechanisms. Different concentrations of DOP had no significant damage to normal GSE-1 cells and gastric intestinal metaplasia model cells by CCK-8 assay. After DOP treatment, the mRNA and protein expression of CDX2 (p < 0.01) and HNF4α (p < 0.01) were decreased, and HO-1 (p < 0.05) and TFF2 (p < 0.01) were increased. The NRF2 protein expression was slightly upregulated (p < 0.05), and H-DOP further promoted NRF2 protein expression in the nucleus (p < 0.05). Hence, our findings reveal that DOP could be used as a potential anti-inflammation supplement by activating NRF2/HO-1 and modulating the HNF4α/CDX2 signaling pathway to inhibit the progress of CDCA-induced gastric intestinal metaplasia. [ABSTRACT FROM AUTHOR]
- Subjects :
- METAPLASIA
CELLULAR signal transduction
DENDROBIUM
POLYSACCHARIDES
INTESTINES
Subjects
Details
- Language :
- English
- ISSN :
- 01458884
- Database :
- Complementary Index
- Journal :
- Journal of Food Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 173485779
- Full Text :
- https://doi.org/10.1155/2023/6668818