Metronidazole-induced cerebellar dysfunction preferentially involving the saccadic system.

Thus, the preferential saccadic impairments and truncal ataxia observed in our patient may corroborate the cerebellar midline lesion observed in most patients. Indeed, metronidazole-associated peripheral neuropathy is found in one-third of patients with metronidazole CNS toxicity [[1]]. C Fluid-attenuated inversion recovery (FLAIR) images show high-signal-intensity lesions involving the dentate nuclei (yellow arrows), superior colliculi (yellow arrowheads), and splenium of the corpus callosum. Notably, a characteristic reversible dentate nuclei lesion is found in 90% of patients [[1], [4]]. [Extracted from the article]