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HLA‐A23/HLA‐A24 serotypes and dementia interaction in the elderly: Association with increased soluble HLA class I molecules in plasma.
- Source :
- HLA: Immune Response Genetics; Dec2023, Vol. 102 Issue 6, p660-670, 11p
- Publication Year :
- 2023
-
Abstract
- MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma‐derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/pre‐dementia (NpD, n = 28), or with dementia (D, n = 28) was studied. Multivariate analysis was used to examine the influence of dementia and HLA class I serotype on sHLA class I levels, and to compare sHLA class I within four groups according to the presence or absence of HLA‐A23/A24 and dementia. HLA‐A23/A24 and dementia, but not age, significantly influenced the level of sHLA class I. Importantly, the concurrent presence of HLA‐A23/A24 and dementia was associated with higher levels of sHLA class I (p < 0.001). This study has shown that the simultaneous presence of HLA‐A23/HLA‐A24 and dementia is associated with high levels of serum sHLA class I molecules. Thus, sHLA class I could be considered a biomarker of neurodegeneration in certain HLA class I carriers. [ABSTRACT FROM AUTHOR]
- Subjects :
- DEMENTIA
ALZHEIMER'S disease
OLDER people
SEROTYPES
NEURAL development
Subjects
Details
- Language :
- English
- ISSN :
- 20592302
- Volume :
- 102
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- HLA: Immune Response Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 173516942
- Full Text :
- https://doi.org/10.1111/tan.15149