Study Data from East China University of Science and Technology Provide New Insights into Neuropeptides (Characterization and Mutagenesis of a High-activity and Highly Substrate-tolerant Dipeptidase for L-carnosine Biosynthesis Via Reversed...).

A recent study conducted by researchers at East China University of Science and Technology has provided new insights into neuropeptides, specifically focusing on the synthesis of L-Carnosine (L-Car). L-Car is a dipeptide with antioxidant and anti-aging effects that is widely used in the pharmaceutical and cosmetic industries. The researchers discovered a dipeptide hydrolase, BmPepD, derived from Bacillus megaterium, which exhibited high synthetic activity for L-Car biosynthesis. Through mutagenesis, they were able to improve the enzyme's activity even further. This research offers a highly active and substrate-tolerant dipeptide hydrolase for the efficient synthesis of L-Car. [Extracted from the article]