SYNTHESIS, CHARACTERIZATION, AND ANTIMICROBIAL STUDIES OF NOVEL BIO-RELEVANT COMPOUNDS DERIVED FROM SUBSTITUTED BENZOTHIAZOLE.

Heterocyclic moieties containing heteroatoms nitrogen, sulfur, and oxygen, such as substituted benzothiazole, have great potential for biological and pharmaceutical importance due to their structural, binding affinity, and photophysical properties. Herein, we have synthesized novel compounds derived from substituted benzothiazole with 2-chloroacetophenone and comparative studies of their mixed ligand metal complexes having 8-hydroxyquinoline. These new compounds were characterized using elemental analysis, magnetic moment determination, molar conductance, melting point determination, and various spectral techniques (FTIR, mass, and 1H NMR spectra). These synthesized compounds were also investigated for their in vitro antimicrobial bioactivity against two bacterial strains; one is gram-positive bacteria Staphylococcus aureus and the second is gram-negative bacteria E. coli and one fungal strain Aspergillus niger using agar well diffusion method and MIC (minimum inhibition concentration) were used to express their antimicrobial activity. Obtained results were compared with Ciprofloxacin and Ketoconazole. Metal complexes possess higher biological activity as compared to free Schiff base ligands in most cases. [ABSTRACT FROM AUTHOR]