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Lipase-catalyzed one-pot four-component reaction in water: green construction of substituted 2,3-dihydrothiophenes.

Authors :
Tang, Yong
Zhang, Kaifu
Xu, Yuelin
Ma, Jinglin
Xie, Hanqing
Zhang, Hongquan
Jiang, Yanmin
Zhao, Rui
Wang, Lei
Source :
New Journal of Chemistry; 11/28/2023, Vol. 47 Issue 44, p20316-20321, 6p
Publication Year :
2023

Abstract

A green and efficient method for the construction of functionalized 2,3-dihydrothiophene derivatives in water was reported. In this work, Novozym 435 acted as a remarkable biocatalyst in catalyzing the four-component reaction of aldehydes, malonitrile or ethyl cyanoacetate, 1,3-thiazolidinedione, and amines under mild conditions. Excellent yields (85–95%) of all the corresponding products could be obtained in reasonable reaction time. Moreover, Novozym 435 could be reused for six cycles with a yield of at least 80%. The rationality of this multicomponent reaction mechanism was also verified via control experiments. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11440546
Volume :
47
Issue :
44
Database :
Complementary Index
Journal :
New Journal of Chemistry
Publication Type :
Academic Journal
Accession number :
173555627
Full Text :
https://doi.org/10.1039/d3nj03722c