Ураження шийки матки на тлі інфікування вірусом папіломи людини: аспекти профілактики, діагностики та лікування.

Cervical cancer (СС) remains a major global health problem, causing significant morbidity and mortality among women worldwide. Despite significant research efforts and advances in screening and prevention strategies, CС remains an unsolved public health challenge, particularly in low- and middle-income countries. Every year in the world, more than half a million women are diagnosed with СС. The article is devoted to the review of modern scientific publications on the prevention, diagnosis and treatment of cervical lesions on the background of human papilloma virus (HPV) infection. Chronic infection with highly oncogenic strains of HPV in 99.7% is a cause of CC development. A comprehensive understanding of the cofactors of the persistence and realization of the oncogenic potential of HPV is crucial for optimizing strategies for early detection, treatment and prevention of recurrences of dysplastic lesions of the cervical epithelium and cervical cancer. A vaginal gel that contains ingredients of natural origin (hyaluronic acid niosomes, glucan niosomes, Centella asiatica phytosomes, Coriolus versicolor extract, Neem extract, prebiotic, Aloe extract vera, etc.) is scientifically based, available for practical use and clinically effective in patients with HPV infection, it makes a protective and therapeutic barrier in the transformation zone of the cervix. The gel blocks the integration of HPV and in such way it prevents the formation of new lesions, acts as an support medication for re-epithelialization of already existing ones, and stimulates the regeneration of the vaginal microbiota. The effectiveness and safety of vaginal use of this gel which include the natural components in women of reproductive age with HPV-associated lesions of the cervical epithelium has been proven (the results of the multicenter open controlled randomized clinical trial PALOMA, 2021). The expediency and effectiveness of its use in women with HPV-associated lesions of the cervical epithelium of late reproductive and perimenopausal age have been established. Improvement and implementation in practice of the prevention system of cervical pathology and making it closer to European standards is a real step towards overcoming the cervical cancer rate. The mentioned vaginal gel is an innovative and safe medicine which contains only natural ingredients, and its therapeutic effect is aimed at increasing the clearance of HPV, repairing intraepithelial lesions of the cervical epithelium and maintaining the normal bacterial microflora of the vagina [ABSTRACT FROM AUTHOR]