Back to Search
Start Over
Short duration of parenteral antibiotics in infants with urinary tract infections.
- Source :
- Paediatrics & Child Health (1205-7088); Nov2023, Vol. 28 Issue 7, p411-416, 6p
- Publication Year :
- 2023
-
Abstract
- Objectives Current guidelines by the Canadian Paediatric Society on treating urinary tract infections (UTIs) exclude infants ≤ 60 days old. There is considerable practice variability in this age group, especially around the optimal duration of parenteral antibiotics. The study aimed to assess local practice patterns, and the safety of a short course (≤3 days) of parenteral antibiotics in young infants. Methods In this retrospective cohort study, 95 infants (≤60 days) with confirmed UTIs were identified at British Columbia Children's Hospital. Patients receiving short (≤3 days) and long (>3 days) duration of parenteral antibiotics were compared. Outcomes of interest included urinary tract infection recurrence within 30 days, hospital length of stay (LOS), representation, and readmission. Results Twenty infants (21%) received a short course of parenteral antibiotics. These infants were older (median 47 days versus 28 days) and non-bacteremic. Urinary tract infection recurrence was identified in 8 patients (8%), of which 7 were treated with a long duration (P = 1.0). Patients treated with a short duration had a significantly shorter LOS, with a mean difference of 4.21 days [95% CI: 3.37 to 5.05] (P < 0.001). All five (5%) bacteremic patients were treated exclusively with parenteral antibiotics. Conclusions In a Canadian setting, a short course of parenteral antibiotics is safe in young, non-bacteremic infants with UTIs. Despite substantial evidence, local practice patterns suggest a tendency towards prescription of long courses, providing an opportunity for quality improvement. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIBIOTICS
INTENSIVE care units
LENGTH of stay in hospitals
BACTEREMIA
CONFIDENCE intervals
URINARY tract infections
TREATMENT duration
PEDIATRICS
RETROSPECTIVE studies
PATIENT readmissions
ANTI-infective agents
PARENTERAL infusions
TREATMENT effectiveness
DISEASE relapse
DRUG prescribing
QUALITY assurance
DESCRIPTIVE statistics
PHYSICIAN practice patterns
DATA analysis software
PATIENT safety
LONGITUDINAL method
CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 12057088
- Volume :
- 28
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Paediatrics & Child Health (1205-7088)
- Publication Type :
- Academic Journal
- Accession number :
- 173587663
- Full Text :
- https://doi.org/10.1093/pch/pxad030