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Coinfection With Severe Fever With Thrombocytopenia Syndrome and Scrub Typhus in Korea.

Authors :
Chatterjee, Shilpa
Kim, Choon-Me
Kim, Dong-Min
Seo, Jun-Won
Kim, Da Young
Yun, Na-Ra
Jung, Sook In
Kim, Uh Jin
Kim, Seong Eun
Kim, Hyun ah
Kim, Eu Suk
Hur, Jian
Kim, Young Keun
Jeong, Hye Won
Heo, Jung Yeon
Jung, Dong Sik
Lee, Hyungdon
Park, Sun Hee
Kwak, Yee Gyung
Lee, Sujin
Source :
Open Forum Infectious Diseases; Oct2023, Vol. 10 Issue 10, p1-4, 4p
Publication Year :
2023

Abstract

Background Scrub typhus and severe fever with thrombocytopenia syndrome (SFTS) are the 2 most common tick-borne infectious diseases in Korea. Every year, an increasing number of cases are reported, which is a public health concern. Therefore, we aimed to investigate the prevalence of SFTS–scrub typhus coinfection in patients with SFTS. Methods Clinical samples were collected from 129 patients with SFTS. One-step reverse-transcription polymerase chain reaction (PCR) was performed to identify the SFTS virus (SFTSV), and real-time PCR followed by nested PCR was performed to detect the Orientia tsutsugamushi gene for scrub typhus. Phylogenetic analysis was conducted to confirm the evolutionary relationships among different species. Results Among 129 SFTS cases, 2 patients with SFTSV were positive for O. tsutsugamushi with a prevalence of coinfection of 1.6% (95% confidence interval,.001–.06). Phylogenetic analysis confirmed these as O. tsutsugamushi strain Boryong. Conclusions Our study found that 1.6% of patients were coinfected with SFTS and scrub typhus infection. We believe that this information will add a new dimension to clinical diagnosis, which should be considered for better public health management. Further research is needed to better understand the ecological transmission dynamics and geographical distribution of SFTSV and O. tsutsugamushi in endemic countries. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23288957
Volume :
10
Issue :
10
Database :
Complementary Index
Journal :
Open Forum Infectious Diseases
Publication Type :
Academic Journal
Accession number :
173588543
Full Text :
https://doi.org/10.1093/ofid/ofad377