Effects of interaction between snoring and hyperuricemia on the metabolic syndrome in school-aged children.

Objective To study the interaction between snoring and hyperuricemia on metabolic syndrome (MetS) in children and adolescents, putting forward targeted countermeasures to prevent and control MetS in the specific subpopulation. Methods Demography data, snoring, anthropometric measurements, and biochemical indicators were obtained from children and adolescents aged 7 - 17 years old who participated in the evaluation and monitoring on school - based nutrition and growth in Shenzhen. Logistic regression model was conducted to evaluate the association between snoring and hyperuricemia on MetS, and an additive model to evaluate the impact of their interaction on MetS. Results The median age of 4 466 participants was 12. 16 years, and 2 454 (54. 9% ) were boys. The detection rates of MetS, snoring, and hyperuricemia accounted for 3. 2%, 29. 3%, and 33. 4% of the total population, respectively. The frequency of snoring < 1 time/week, 1-2 times/week, and ^ 3 times/week were positively correlated with MetS disease and showed a gradually increasing trend (P trend <0. 001). Snoring (OR =2.085, 95% CI- 1.462 -2.902) and hyperuricemia (OR = 4. 741, 95% CI- 3. 144 -7. 148) were both associated with MetS. In addition, there was no multiplicative interaction between snoring frequency, snoring, and high uric acid on MetS, but snoring and high uric acid had an additive interaction on MetS [ relative excess risk due to interaction = 3. 801 (0. 060 - 7. 542), attributable proportion of interaction = 0. 418 (0. 154 - 0. 683), synergy index = 1. 887 (1. 101 - 3. 234) ] . Conclusion Snoring and hyperuricemia are both risk factors for MetS. There is a synergistic effect between snoring and hyperuricemia on the risk of MetS. Therefore, it is necessary to actively control weight, maintain positive airway pressure ventilation, orthodontic treatment, limit fried foods, meat, seafood, and increase vegetable intake to improve snoring and uric acid levels in children and adolescents, in order to achieve prevention and management of MetS. [ABSTRACT FROM AUTHOR]