Protective Effect of Ethanol Extract from Sweet Potato Leaves on CCL4 -Induced Liver Injury in Mice.

[Objectives] To investigate the protective effect of ethanol extract from sweet potato leaves on liver injury induced by CC1₄ in mice. [Methods] 25 ICR mice were randomly divided into blank group, model group, high-dose extract group (200 mg/kg), low-dose extract group (100 mg/kg) and positive control group (2 mg/kg colchicine), with 5 mice in each group. All groups except the blank group were given intraperitoneal injection of 20% CC14 olive oil solution (2 mL/kg), and the blank group was given the same dose of olive oil solution three times a week. After 4 weeks, each administration group was given the corresponding dose of drugs (10 mL/kg), and the blank group and model group were given the corresponding amount of normal saline for 2 weeks. After the last intragastric administration, fasting was required, but water was allowed, blood was taken from eyeballs, and upper serum was taken by static centrifugation. Serum AST, ALT, CRP, IL-6 and SOD levels were detected by the kit. [Results] Compared with the blank group, the serum AST and ALT levels in the model group were significantly increased; compared with the model group, the ethanol extract of sweet potato leaves could decrease the levels of ALT, AST, CRP, IL-6 and increase the level of SOD in serum. [Conclusions] The ethanol extract of sweet potato leaves had protective effect on the mice with liver injury induced by CC14, and its mechanism may be to protect the liver by lowering enzymes, inhibiting inflammation and antioxidant stress. [ABSTRACT FROM AUTHOR]