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Melanin-targeted [18F]-PFPN PET imaging may shed light for clear cell sarcoma.
- Source :
- European Journal of Nuclear Medicine & Molecular Imaging; Dec2023, Vol. 51 Issue 1, p196-201, 6p
- Publication Year :
- 2023
-
Abstract
- Purpose: Intracytoplasmic melanin pigment is a characteristic of clear cell sarcoma (CCS), which is a particularly deadly type of soft-tissue sarcoma. [<superscript>18</superscript>F]-N-(2-(diethylamino)ethyl)-5-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)picolinamide ([<superscript>18</superscript>F]-PFPN) is a positron emission tomography (PET) probe characterized by high melanin affinity. Therefore, this study aimed to investigate the feasibility of melanin-targeted [<superscript>18</superscript>F]-PFPN PET in patients with CCS. Methods: This prospective single-centre study recruited patients with pathologically confirmed CCS. [<superscript>18</superscript>F]-FDG PET/computed tomography and [<superscript>18</superscript>F]-PFPN PET/magnetic resonance imaging scans were performed within 1 week of each other. The lesion numbers and [<superscript>18</superscript>F]-FDG and [<superscript>18</superscript>F]-PFPN PET parameters (maximum standardized uptake value [SUVmax], mean standardized uptake value [SUVmean], metabolic/melanotic tumour volume [MTV/MLTV], and total lesion glycolysis/melanin [TLG/TLM]) were collected. Results: Three patients with CCS were recruited and received PET imaging. A total of 56 lesions were detected on [<superscript>18</superscript>F]-PFPN PET, including primary tumour and distant metastases. Identical lesions were not detected on [<superscript>18</superscript>F]-PFPN and [<superscript>18</superscript>F]-FDG PET. Twelve lesions (12/39, 30.77%) on [<superscript>18</superscript>F]-FDG imaging were missed on [<superscript>18</superscript>F]-PFPN, and 20 lesions (20/47, 42.55%) on [<superscript>18</superscript>F]-PFPN imaging were missed on [<superscript>18</superscript>F]-FDG. In quantitative analysis, the [<superscript>18</superscript>F]-FDG SUVmean (4.60 ± 3.24) was higher than the [<superscript>18</superscript>F]-PFPN SUVmean (3.0 ± 2.63) in all lesions (P = 0.01). No significant correlations were found between the SUVmax, SUVmean, MLTV/MTV, and TLM/TLG values of [<superscript>18</superscript>F]-PFPN and [<superscript>18</superscript>F]-FDG (P > 0.05). Conclusion: Melanin-targeted [<superscript>18</superscript>F]-PFPN PET imaging is feasible for the diagnosis of CCS. Different imaging features were displayed on [<superscript>18</superscript>F]-PFPN and [<superscript>18</superscript>F]-FDG PET imaging, demonstrating the complementary role of the tracers. Combined use of the two imaging modalities would be preferred in patients with CCS. Clinical Trial Registration: NCT05963035. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16197070
- Volume :
- 51
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- European Journal of Nuclear Medicine & Molecular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 173894154
- Full Text :
- https://doi.org/10.1007/s00259-023-06439-2