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Association Between Maternal Mood Disorders and Schizophrenia and the Risk of Type 1 Diabetes in Offspring: A Nationwide Cohort Study.
- Source :
- Neuropsychiatric Disease & Treatment; Nov2023, Vol. 19, p2511-2518, 8p
- Publication Year :
- 2023
-
Abstract
- Our study aimed to determine whether mothers with bipolar disorder, major depressive disorder, schizophrenia, or schizoaffective disorder affected the risk of type 1 diabetes (T1D) in their offspring.Methods: We conducted a nationwide cohort study by using data from Taiwan's National Health Insurance Research Database and the Maternal and Child Health Database from 2004 to 2018. A total of 2,556,640 mother-child pairs were identified. Cox proportional hazards models were used to compare the risk of T1D between children born to mothers with mood disorders and schizophrenia and those without.Results: No significant difference in risk of T1D was observed between the offspring of mothers with major psychiatric disorders and those without (adjusted hazard ratio (aHR) of 0.86 with a 95% confidence interval (CI) of 0.58– 1.24). In subgroup analysis, we found an aHR of 1.81 with a 95% CI of 0.83– 3.82 in the maternal bipolar disorder on the risk of T1D in offspring and an aHR of 0.87 (95% CI: 0.59– 1.25) in maternal major depressive disorder. In the schizophrenia/schizoaffective disorder group, aHR cannot be obtained due to lesser than three events in the analysis.Conclusion: The risk of T1D in offspring of mothers with mood disorders and schizophrenia was not significant. However, children born to mothers with bipolar disorder may have a tendency to develop T1D. The relationship between maternal psychiatric disorders and the risk of T1D in offspring warrants further investigation in studies with longer follow-up periods. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11766328
- Volume :
- 19
- Database :
- Complementary Index
- Journal :
- Neuropsychiatric Disease & Treatment
- Publication Type :
- Academic Journal
- Accession number :
- 173929309
- Full Text :
- https://doi.org/10.2147/NDT.S437430