Research Results from First Affiliated Hospital of Guangzhou Medical University Update Knowledge of Science and Technology (Differentiation between lung allograft rejection and infection using donor-derived cell-free DNA and pathogen detection...).

A study conducted at the First Affiliated Hospital of Guangzhou Medical University in China aimed to differentiate between lung allograft rejection and infection in lung transplant recipients (LTRs) using plasma donor-derived cell-free DNA (dd-cfDNA) and metagenomic next-generation sequencing (mNGS) for pathogen detection. The study found that elevated levels of plasma dd-cfDNA, in combination with negative mNGS results, strongly indicated lung allograft rejection. The research concluded that plasma dd-cfDNA, along with BALF pathogen detection by mNGS, showed satisfactory accuracy in distinguishing between lung allograft rejection and infectious complications in LTRs. [Extracted from the article]