A Three-Month Clinical Study to Assess the Gingivitis and Plaque Effects of Various Dentifrices.

A clinical trial, NCT06140784, is currently underway to examine the effects of four different toothpastes on gingivitis and plaque after 12 weeks of use. The main goal of the trial is to determine the impact of the toothpastes on gingivitis, while also evaluating their effects on plaque and the composition of the oral microbiome. The trial is being conducted by Procter and Gamble and is expected to be finished on December 10, 2023. The document provides details about the trial, including the use of a 0.454% Stannous Fluoride Dentifrice for brushing the entire mouth twice daily. The trial is active but not recruiting participants, and it is open to individuals who are at least 18 years old, in good general health, and have mild to moderate gingivitis. The trial is taking place in the United States and is sponsored by Procter and Gamble. The document also includes administrative information such as the NCT number and responsible party. [Extracted from the article]