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A critical function for type I interferons in cancer immunoediting.
- Source :
- Nature Immunology; Jul2005, Vol. 6 Issue 7, p722-729, 8p
- Publication Year :
- 2005
-
Abstract
- 'Cancer immunoediting' is a process wherein the immune system protects hosts against tumor development and facilitates outgrowth of tumors with reduced immunogenicity. Although interferon-γ (IFN-γ) is known to be involved in this process, the involvement of type I interferons (IFN-α/β) has not been elucidated. We now show that, like IFN-γ, endogenously produced IFN-α/β was required for the prevention of the growth of primary carcinogen–induced and transplantable tumors. Although tumor cells are important IFN-γ targets, they are not functionally relevant sites of the actions of the type I interferons. Instead, host hematopoietic cells are critical IFN-α/β targets during development of protective antitumor responses. Therefore, type I interferons are important components of the cancer immunoediting process and function in a way that does not completely overlap the functions of IFN-γ. [ABSTRACT FROM AUTHOR]
- Subjects :
- INTERFERONS
CANCER
IMMUNE system
ANTINEOPLASTIC agents
CANCER cells
TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 15292908
- Volume :
- 6
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Nature Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 17395494
- Full Text :
- https://doi.org/10.1038/ni1213