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Half versus normal saline irrigation during catheter ablation of outflow tract ventricular arrhythmias (HALF): a multi-center, parallel, open-label, randomized controlled study.
- Source :
- Journal of Interventional Cardiac Electrophysiology; Dec2023, Vol. 66 Issue 9, p2143-2151, 9p
- Publication Year :
- 2023
-
Abstract
- Background: Animal studies demonstrated that deeper lesions could be achieved during radio-frequency catheter ablation (RFCA) by using half saline (HS) compared to normal saline (NS) as irrigation. Objectives: This study sought to compare the efficiency and safety of HS and NS for irrigation during RFCA of idiopathic outflow tract ventricular arrhythmia (OT-VA). Methods: In this multicenter, randomized controlled study, 167 patients undergoing RFCA of OT-VA were randomized 1:1 to receive HS- or NS-irrigated ablation. Acute success was defined as the absence of induced targeted premature ventricular contraction (PVC) at the end of the procedure. The 6-month success was defined as a ≥ 80% reduction of pre-procedural PVC burden. Results: There were no differences of baseline characteristics between the HS and NS group. Patients in HS group had shorter total ablation time (259.5 ± 155.5 S vs. 355.6 ± 230.7 S, P = 0.04) than that in NS group. The acute and 6-month success rates were similar between the HS and NS group (92.8 vs. 91.7%, P = 0.79; 90.9 vs. 92.1%, P = 0.79, respectively). No significant difference was observed in the incidence of steam pops between the HS and NS group (2.4 vs. 1.2%, P = 0.62). Conclusions: The ablation using HS irrigation achieved similar success rate and safety compared to that using NS irrigation but was associated with a shorter total ablation time. Trial registration: Chinese Clinical Trial Registry (ChiCTR2200059205) [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1383875X
- Volume :
- 66
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Journal of Interventional Cardiac Electrophysiology
- Publication Type :
- Academic Journal
- Accession number :
- 173964136
- Full Text :
- https://doi.org/10.1007/s10840-023-01558-0