Back to Search Start Over

Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis.

Authors :
Russo, Elena
Guizzardi, Mathilda
Canali, Luca
Gaino, Francesca
Costantino, Andrea
Mazziotti, Gherardo
Lania, Andrea
Uccella, Silvia
Di Tommaso, Luca
Ferreli, Fabio
Malvezzi, Luca
Spriano, Giuseppe
Mercante, Giuseppe
Source :
Reviews in Endocrine & Metabolic Disorders; Dec2023, Vol. 24 Issue 6, p1205-1216, 12p
Publication Year :
2023

Abstract

Background: Inflammation has been associated with tumor development and circulating inflammatory biomarkers have been proposed as possible predictors of recurrence of several solid tumors. However, the role of inflammation markers in differentiated thyroid carcinoma (DTC) is still uncertain. Objective: This meta-analysis aimed to assess the prognostic value of neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR) in patients with DTC. Methods: Studies investigating the association between survival and preoperative circulating inflammatory markers in DTC patients were included. The primary outcome was disease-free survival (DFS). Cumulative logarithms of the hazard ratio (log-HRs) with 95% CI were calculated through the inverse variance method using a random-effects model. Results: A total of 7599 patients with a mean age of 48.89 (95% CI 44.16–53.63) were included. The estimated pooled log-HRs for DFS were 0.07 for NLR (95% CI -0.12–0.26; p = 0.43), -0.58 for LMR (95% CI -1.21–0.05; p = 0.06), and 0.01 (95% CI 0–0.01; p = 0.21) for PLR. Conclusions: Our meta-analysis showed no association between NLR, PLR, LMR and DFS in DTC; however, more prospective data are needed to better define the association between inflammatory status and prognosis of DTC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13899155
Volume :
24
Issue :
6
Database :
Complementary Index
Journal :
Reviews in Endocrine & Metabolic Disorders
Publication Type :
Academic Journal
Accession number :
174014245
Full Text :
https://doi.org/10.1007/s11154-023-09845-x