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Effect of concomitant atrial septal defect on left ventricular function in adult patients with unrepaired Ebstein's anomaly: a cardiovascular magnetic resonance imaging study.
- Source :
- Journal of Cardiovascular Magnetic Resonance (BioMed Central); 12/7/2023, Vol. 25 Issue 1, p1-10, 10p
- Publication Year :
- 2023
-
Abstract
- Background: Due to the heterogeneity of anatomic anomalies in Ebstein's anomaly (EA), particularly in the subset of patients with atrial septal defect (ASD), hemodynamic changes, which ultimately cause left ventricular (LV) deterioration remain unclear. The current study aimed to investigate the effect of concomitant ASD on LV function using cardiovascular magnetic resonance (CMR) imaging in patients with EA. Methods: This study included 31 EA patients with ASD, 76 EA patients without ASD, 35 patients with simple ASD and 40 healthy controls. Left/right ventricular (RV, the RV was defined as a summation of the functional RV and atrialized RV in EA patients) volumes and functional parameters, LV strain parameters, and echocardiogram indices were compared among the four groups. Associations between variables were evaluated via Spearman or Pearson correlation analyses. The association between risk factors and LV ejection fraction (EF) was determined via multivariate linear regression analysis. Results: Both EA patients and ASD patients had a higher RV/LV end-diastolic volume (RVEDV/LVEDV) as well as lower LV and RV ejection fractions (LVEF/RVEF) compared to healthy controls (all p < 0.05). Moreover, the EA patients with ASD had a significantly higher RVEDV/LVEDV and a lower LVEF and RVEF than those without ASD (all p < 0.05). Multivariate linear regression analysis revealed that the presence of ASD was independently associated with LVEF (β = − 0.337, p < 0.001). The RVEDV/LVEDV index was associated with LVEF (r = − 0.361, p < 0.001). Furthermore, the LV longitudinal peak diastolic strain rate (PDSR) was lower in EA patients with ASD than those without ASD, patients with simple ASD, and healthy controls (p < 0.05). Conclusion: Concomitant ASD is an important risk factor of LV dysfunction in patients with EA, and diastolic dysfunction is likely the predominate mechanism related to LV dysfunction. [ABSTRACT FROM AUTHOR]
- Subjects :
- LEFT heart ventricle
STATISTICS
VENTRICULAR ejection fraction
MULTIVARIATE analysis
LEFT ventricular dysfunction
CARDIOVASCULAR diseases
MAGNETIC resonance imaging
REGRESSION analysis
ATRIAL septal defects
COMPARATIVE studies
PEARSON correlation (Statistics)
RISK assessment
EBSTEIN'S anomaly
RESEARCH funding
HEART physiology
DATA analysis
STROKE volume (Cardiac output)
DISEASE risk factors
DISEASE complications
ADULTS
Subjects
Details
- Language :
- English
- ISSN :
- 1532429X
- Volume :
- 25
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Cardiovascular Magnetic Resonance (BioMed Central)
- Publication Type :
- Academic Journal
- Accession number :
- 174028669
- Full Text :
- https://doi.org/10.1186/s12968-023-00976-3