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The effect of a preparation containing glycocholic acid on the biocidal efficacy of sodium hypochlorite in a biofilm laboratory model.
- Source :
- Australian Endodontic Journal; Dec2023, Vol. 49 Issue 3, p503-511, 9p
- Publication Year :
- 2023
-
Abstract
- This study assessed the antimicrobial effect of sodium hypochlorite (NaOCl) mixtures combined with Keratobacter (KB) using an engineered biofilm root canal model. Clinical and reagent grade NaOCl were mixed with KB (9:1‐vol/vol) to assess pH values over 1 min to select the ideal solution with a pH just below the pKa of hypochlorous acid. The samples were randomly divided into five groups: 1% and 4% NaOCl reagents, a mixture of NaOCl:KB using 1% and 4% NaOCl reagents and distilled water. Outcome measures were colony‐forming units (CFUs/mL) and positive/negative cultures. No significant differences were observed in the pairwise comparisons between 1%, 4% NaOCl and 4% NaOCl+KB for the outcome CFUs/mL. Only 4% NaOCl presented with negative cultures in all samples, whereas 1% NaOCl and 4% NaOCl+KB had similar results (54% vs. 40%). The addition of KB has a limited effect on the antimicrobial efficacy of 4% NaOCl in this laboratory model. [ABSTRACT FROM AUTHOR]
- Subjects :
- SODIUM hypochlorite
BIOFILMS
HYPOCHLORITES
DENTAL pulp cavities
DISTILLED water
ACIDS
Subjects
Details
- Language :
- English
- ISSN :
- 13291947
- Volume :
- 49
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Australian Endodontic Journal
- Publication Type :
- Academic Journal
- Accession number :
- 174181679
- Full Text :
- https://doi.org/10.1111/aej.12771